组织因子途径抑制物与冠心病的相关性研究
The Correlation between Tissue Factor Pathway Inhibitor and Coronary Heart Disease
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摘要: 目的观察不同类型冠心病患者外周血血浆中组织因子途径抑制物(TFP)I抗原水平变化,探讨TFPI在冠心病发生发展中的作用及其临床相关性.方法对66例CHD患者和22例非冠心病的正常对照者进行研究.AMI患者和UAP患者在入院后即刻应用低分子肝素抗凝治疗前抽取外周静脉血,SAP患者和正常对照组患者在入院后次日清晨空腹抽血,血标本离心处理提取血浆,超低温冻存备用.所有入选对象均行冠状动脉造影检查明确冠状动脉病变情况,检测血清总胆固醇、甘油三脂、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平.采用酶联免疫吸附法检测AMI组、UAP组、SAP组和正常对照组患者血浆中TFPI-1、TFPI-2抗原水平,应用SPSS13.0统计软件包对数据进行统计分析.结果(1)AMI组和UAP组患者血浆TFPI-1抗原水平分别为(32.05±8.52)ng/mL和(31.49±10.61)ng/mL,高于SAP组(19.93±9.22)ng/mL和正常对照组(19.21±9.60)ng/mL,差异有统计学意义(P<0.05),AMI组和UAP组、SAP组和正常对照组之间差异无统计学意义(P>0.05);(2)AMI组和UAP组患者血浆TFP...Abstract: Objective To investigate the changes of plasma levels of TFPI in different type of CHD patients and the association with coronary heart disease.Methods This study was conducted in 66 CHD patients and 22 healthy adults.The blood specimens were collected before using LMWH in AMI patients;and the blood specimens of SAP patients and healthy adults were collected on the second morning.After centrifugal treatment,the plasma was saved in a ultra-low temperature refrigerator.Coronary angiography was carried out on ...
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Key words:
- Coronary heart disease /
- Tissue factor /
- Tissue factor pathway inhibitor
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