摘要:
目的探讨血清同型半胱氨酸(homocysteine,Hcy)水平与冠脉病变的相关性.方法收集2010年8月至2011年9月于玉溪市人民医院心内科行冠状动脉造影的患者340例,分为冠心病组包括稳定性心绞痛(stable angina,SA)组、不稳定性心绞痛(unstable angina,UA)组、急性心肌梗死(acute myocardial infarction,AM)I组及正常对照组,所有入选对象均进行冠脉病变程度积分(Genesine积分)及血清Hcy水平测定.结果(1)与对照组相比,冠心病组(包括SA、UA及AMI组)血清Hcy水平显著升高(P<0.01),与SA组相比,UA组、AMI组血清Hcy水平显著升高(P<0.01),与UA组相比,AMI组血清Hcy水平显著升高(P<0.01);(2)多元逐步线性回归分析及二元Logistic回归分析显示,除外性别、年龄、血糖、血脂等因素,血清Hcy仍与冠脉病变的严重程度相关,与斑块的不稳定性相关;(3)ROC曲线分析显示血清Hcy鉴别斑块不稳定性的敏感性和特异性优于低密度脂蛋白胆固醇(LDL-C)及Genesini积分.结论血清Hcy与冠脉病变严重程度相关...
Abstract:
Objective To investigate the association between serum homocyteine(Hcy)and coronary arteriosclerosis.Methods 340 patients in our hospital who had cronary anginography were divided into 4groups: stable angina(SA)group,unatable angina(UA)group,acute myocardial infarction(AMI) group and control group.Gensine score and the level of serum Hcy were determinated in all cases.Results(1)Compared with control group,the serum Hcy levels were significantly higher in all groups with coronary heart desease(P< 0.01),incre...
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