老年癌痛与抑郁的相关性及其对免疫功能的影响研究
Correlation between Pain and Depression and Their Effect on Immune Function in Elderly Cancer Patients
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摘要: 目的 探讨老年癌痛与抑郁的相关性,以及疼痛、抑郁对免疫功能的影响.方法 对经病理确诊的老年癌症并伴有疼痛的患者进行抑郁自评量表问卷调查,同时采集血清进行免疫功能测定,并与无疼痛的老年癌症患者比较.结果 有疼痛与无疼痛的两组患者抑郁的发生无统计学意义(P>0.05),但疼痛与抑郁程度有相关性,老年癌痛患者重度抑郁的发生率较高(P<0.05);有疼痛与无疼痛的两组患者NK细胞比较有统计学意义(P<0.05),CD3+、CD4+、CD8+比较无明显统计学意义;抑郁组与无抑郁组免疫功能无统计学意义(P>0.05).结论 老年癌症患者疼痛与抑郁的发生无相关性,与抑郁程度有相关性,对NK细胞有影响,对CD3+、CD4+、CD8+无明显影响;老年癌痛患者重度抑郁的发生率较高,对免疫功能无影响.Abstract: Objective To explore the correlation between cancer pain and depression in elderly patients,and the effect of pain and depression on immune function.Methods 49 elderly cancer patients with pain and 60 aged cancer patients without pain controls(diagnosed by pathology)were tested with Self-Rating Depression scale(SDS),Simultaneous venous blood samples were collected from all of the 109 patients for measurement of immune function.Results There were no obvious statistical differences in the incidence rate of de...
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Key words:
- Elderly cancer pain /
- Depression /
- Immune function
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