非小细胞肺癌并恶性心包腔积液双路径化疗临床疗效分析
Clinical Effects of Double-way Chemotherapy on Non-small Cell Lung Cancer with Malignant Pericardial Effusion
-
摘要: 目的 探讨晚期非小细胞肺癌并恶性心包腔积液双路径化疗的疗效.方法 选择42例经细胞学和/或组织学确诊的非小细胞肺癌并恶性心包腔积液的患者,所有患者均行心包腔置管闭式引流,随机分为A组和B组,每组各21例.A组患者应用全身化疗+心包灌注CDDP(顺铂)及IL-2(重组人白细胞介素-2)治疗,B组患者应用全身化疗+心包灌注CDDP治疗.结果 42例晚期非小细胞肺癌并心包膜腔积液患者双路径化疗的RR为73.8%(31/42).其中,A组21例患者的CR为76.2%(16/21),PR为14.3%(3/21),RR为90.5%(19/21);B组21例患者的CR为33.3%(7/21),PR为23.8%(5/21),RR为57.1%(12/21).比较A组和B组患者的总有效率,差异有统计学意义(P＜0.05).结论 心包膜腔积液系晚期非小细胞肺癌常见并发的急症,在短期内致心脏填塞威胁患者的生命,全身化疗加心包膜腔内灌注CDDP联合IL-2的双路径化疗方法治疗晚期非小细胞肺癌所致恶性心包积液,近期疗效好,值得在临床进一步探讨.Abstract: Objective To investigate the effect of double-way chemotherapy on non-small cell lung cancer with malignant pericardial effusion.Method We selected 42 cases of confirmed non-small cell lung cancer with malignant pericardial effusion by cytological and / or histological examination.All 42 patients underwent pericardial cavity closed drainage,and were randomly divided into A group and B group(21 patients in each goroup).Patients in A group were ginven systemic chemotherapy with pericardial perfusion treatment...
-
点击查看大图
计量
- 文章访问数: 1958
- HTML全文浏览量: 615
- PDF下载量: 29
- 被引次数: 0
下载:
