腹腔镜卵巢打孔术后应用二甲双胍和克罗米芬治疗多囊卵巢综合征
Clinical Effects of Metformin Combined with Clomiphene in Treament of PCOS after Laparoscopic Ovarian Drilling
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摘要: 目的 评估腹腔镜卵巢打孔术(laparoscopic ovarian drilling,LOD)后应用二甲双胍和克罗米芬治疗多囊卵巢综合征的疗效.方法 2002年1月至2010年6月对40例在文山州医院妇科经克罗米芬治疗后无排卵及月经未恢复正常的PCOS患者进行腹腔镜卵巢电凝打孔术,术后服用二甲双胍和克罗米芬促排卵,根据基础体温和B超及尿HCG检测观察排卵及妊娠情况.术前及术后分别抽血测LH、FSH、T 及E2 ; 结果与术前相比较.结果 术后血清LH,LH/FSH,T水平较术前明显下降(P<0.01),而FSH,E2无明显变化(P>0.05),大部分患者月经情况明显改善,术后3个月自然排卵率72.5%,术后24 个月累计妊娠率65%.无卵巢过度刺激综合症(OHSS)发生.结论 应用克罗米芬促排卵治疗后仍无妊娠的患者,腹腔镜下卵巢打孔术后应用二甲双胍和克罗米芬,可明显改善患者高雄激素血症和月经状况,促进排卵,提高妊娠率.Abstract: Objective To evaluate the effects of Metformin combined with clomiphene in treatment of polycystic ovary syndrome(PCOS)after laparoscopic ovarian drilling(LOD).Methods 40 cases of PCOS whose ovulation and menstruation did not resume after treatment with clomiphene,were treated by LOD in the Department of Gynecology from Jan 2002 to Jun 2010,then administrated with Metformin and clomiphene to stimulate ovulation after the operation.The preoperative and postoperative levels of serum LH,FSH,T and E2 were measu...
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Key words:
- Polycystic ovary syndrome /
- Laparoscopi8c ovarian drilling /
- Metformin /
- Clomiphene
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