摘要:
目的 探讨7.5%的高渗盐水治疗急性颅外伤初期患者的临床效果.方法 将30例急性颅脑外伤的患者随机分为两组:甘露醇组(MT)15例和高渗盐水组(HS)15例,分别滴注20%甘露醇和7.5%高渗盐水,并观察用药前和用药后的心率、呼吸、颅内压(ICP),平均动脉压(MAP),中心静脉压(CVP).用药前及用药后第1、3、7天测患者尿量,电解质,肾功能变化.结果 用药前相比,用药后6 h两组的心率、呼吸、MAP及CVP用药前后相比无明显变化;在降颅压方面,HS组作用高峰快于MT组,并且维持降颅内压时间较长.尿量HS组少于MT组,HS组患者治疗后第1、3、7天血清K+、Na+、Cl-、尿素氮、肌酐均无显著改变(P＞0.05);M组患者血清K+、Na+、Cl-、肌酐均无显著改变,但用药后第7天的尿素氮值较同期HS组显著升高(P＜0.05).结论 HS在急性颅脑外伤早期治疗中能有效降低 ICP,改善器官血流灌注,相比MT,起效更快,更持久.
Abstract:
Objective To evaluate the curative effects of 7.5%hypertonic saline on patients with acute traumatic brain injury.Methods Thirty patients with acute brain injury were randomly divided into 2 groups:mannitol(MT)group and hypertonic saline group(HS),15 patients in each group.Patients in MT group and HS group were given 20% mannitol and 7.5%hypertonic saline,respectively.We observed the heart rate,respiration,intracranial pressure(ICP),mean arterial pressure(MAP),and central venous pressure(CVP) of patients in...
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