Abstract: Objective To explore a simple,safe and effective anesthetic method in miniature swines' burn wounds and skin graft experiments.Methods Combined anesthesia was performed by using ketamine combined with midazolam and pentobarbital.Anesthesia induction was done by intramuscular injection of mixing ketamine and midazolam to the swine,and anesthesia was maintained by intravenous injection with 3% pentobarbital,and the anesthesia times,the analgesic effects,the respiratory rate,heart rate and the recovery time af...