摘要:
目的 探讨Syndecan-1、CD54、RAB5A在胃癌原发灶中的表达情况及其三者之间的相关性.方法 用免疫组织化学染色的方法分别检测了Syndecan-1、CD54和RAB5A在46例胃癌原发灶,癌旁3.0 cm,癌旁10.0 cm,正常组织(外伤或病理证实为良性溃疡)内的表达情况.结果 Syndecan-1在胃癌原发灶内的阳性表达率为15.22%(7/46),癌旁3.0 cm组织,癌旁10.0 cm组织,正常组织中的阳性表达率分别为28.26%(13/46)、86.96%(40/46)100%(12/12).CD54在胃癌原发灶内的阳性表达率为67.39%(31/46),癌旁3.0cm,癌旁10.0 cm和正常组织中分别为54.35%(25/46),8.70%(4/46),0.00%(0/12).RAB5A在胃癌组织中阳性表达率为78.26%(36/46),癌旁3.0 cm,癌旁10.0 cm和正常组织阳性表达率分别为63.04%(29/46),17.39%(8/46)和0.00%(0/12);Syndecan-1的表达与CD54的表达在胃癌组织中呈负相关(r=-0.351,P=0.017).Syndecan-1的表达与RAB5A在胃癌组织中呈负相关(r=-0.364,P=0.013);CD54与RAB5A在胃癌组织中呈正相关(r=0.645,P=0.000).结论 Syndecan-1在胃癌原发灶组织中呈低表达,与CD54、RAB5A呈负相关,CD54和RAB5A在胃癌原发灶组织中均呈高表达,并两者正相关,可能对肿瘤进展、恶性程度的判断和发生机制具有重要意义.
Abstract:
Objective To investigate the expression of Syndecan-1,CD54 and RAB5A in gastric carcinoma and their relationship.Methods Immunohistochemistry staining(S-P method) was used to detect the expression of Syndecan-1,CD54 and RAB5A on consecutive section in 46 cases of gastric cancer,paracancer 3.0 cm,paracancer10.0 cm and 12 case of normal tissues(trauma or benign ulcer verified by pathology).Results The positive expression rate of Syndecan-1 in gastric cancer,paracancer 3.0 cm,paracancer10.0 cm and normal tissu...
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