肝癌中ADAM10、EGFR和E-cadherin的表达分析及其与临床病理关系的研究
The Expressions and Significance of ADAM10,EGFR and E-cadherin in Hepatocellular Carcinoma
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摘要: 目的探讨ADAM10、EGFR和E-cadherin在肝细胞癌组织中的表达及意义.方法运用免疫组化法和实时定量PCR检测ADAM10、EGFR和E-cadherin在肝癌组织中的表达,并分析及其与临床病理关系的研究.结果 EGFR和ADAM10在肝癌和癌旁组织中均有表达,但在癌组织中EGFR和ADAM10的阳性表达率显著高于癌旁组织,而E-cadherin表达低于癌旁组织(P<0.05).ADAM10、EGFR和E-cadherin在肝癌组织中的表达与门静脉癌栓形成、肝内转移、分化程度、肿瘤大小及肿瘤转移有关.结论 ADAM10、EGFR和E-cadherin的检测对了解肝癌的发生发展,指导治疗和判断预后有重要意义.
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关键词:
- 肝癌 /
- ADAM10 /
- EGFR /
- E-cadherin /
- 表达
Abstract: Objective To investigate the expressions and significance of ADAM10,EGFR and E-cadherin in hepatocellular carcinoma.Methods Immunohistochemistry and real time PCR were used to detect the expressions of ADAM10,EGFR and E-cadherin in 40 cases of hepatocellular carcinoma and analyze their relationshipship with clinic pathorelation.Results The expressions of ADAM10,EGFR and E-cadherin were significantly related to cancer epistom in portal vein,transplantation in liver,cell differentiation,size of cancer,and dis...-
Key words:
- Hepatocellular carcinoma /
- ADAM10 /
- EGFR /
- E-cadherin /
- Expression
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