人脑胶质瘤中proNGF凋亡前信号的研究
Study on proNGF Apoptosis Pro-signal in Human Brain Gliomas
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摘要: 目的探讨proNGF(Nerve growth factor precurso)r凋亡前信号在人脑胶质瘤中的表达及其临床意义.方法采用RTPCR(Rever Transcription Poly-merase Chain Reaction)技术检测人脑胶质瘤中proNGF凋亡前信号各因子proNGF、Sortilin及P75的表达,以10例瘤周正常脑组织为对照.结果各因子在胶质瘤中均有表达,正常脑组织中低表达,两组之间比较差异有统计学意义(P<0.05).结论 proNGF凋亡前信号所导致的细胞凋亡参与正常人脑组织及胶质瘤的发生、发展过程,可能是一种正常机体的保护性机制.Abstract: Objective To observe the expressional changes of proNGF apoptosis pro-signal molecules in human brain gliomas and its clinical meanings.Methods RT-PCR(Reverse transcription poly-merase chain reaction)was used to detect the expressional changes of proNGF,Sortilin and P75 in human brain gliomas,and 10 cases of normal tissue around the gliomas were used as the control.Results All the factors were detected in gliomas,and lowly expressed in normal tissues,and there was statistically significant difference betwee...
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