摘要:
目的观察联合应用阿司匹林、阿托伐他汀、普罗布考(PAS疗法)对于动脉粥样硬化的疗效.方法随机将昆明医学院第二附属医院120例缺血性脑血管病合并颈动脉粥样硬化患者,将其分为PAS治疗组、AS对照组和A对照组,进行比较研究.PAS治疗组40例,应用普罗布考(0.5 g/d),阿司匹林(100mg/d),阿托伐他汀钙(20 mg/d);AS对照组40例,予阿司匹林(100 mg/d),阿托伐他汀钙(20 mg/d);A对照组40例仅给予阿司匹林(100 mg/d).共随访3个月,分别在治疗前,治疗后3个月检测血脂(TC、TG、LDL-C、HDL-C)及血清高敏C反应蛋白(hs-CRP),比较颈动脉内-中膜厚度(IMT)及颈动脉斑块积分的变化.结果治疗后PAS治疗组及AS对照组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及hs-CRP含量均下降(P<0.05),PAS治疗组更明显(P<0.01);PAS治疗组的颈动脉斑块积分有轻微下降趋势(P>0.05).结论 (1)阿司匹林、阿托伐他汀、普罗布考联合治疗动脉粥样硬化调脂、降低炎症指标hs-CRP效果明显优于单用阿司匹林,也较阿司匹林、阿托伐他汀联用效果明显;(...
Abstract:
Objective To investigate the effects of combination therapy of probucol,atorvastatin calcium and aspirin drugs(PAS)on patients with atherosclerosis.Method 120 patients with ischemic cerebrvascular disease and carotid arteriosclerosis were randomly divided into three groups:PAS group,AS group and A group,40 patients in each group.Patients in the PAS group were treated with probucol(0.5 g/d),atorvastatin calcium(20 mg/d)and aspirin(100 mg/d),patients in AS group were treated with atorvastatin calcium(20 mg/d)...
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