Abstract: Objective　To investigate a steady way which named“intravenously guttae”of preparation of hyperkalemia in rabbit，and compare two different treatment methods polarized solution treatment and sodium bicarbonate treatment．Methods　30 rabbits were randomly divided into 3 groups：Saline group，polarized solution（glucose-insulin）group and sodium bicarbonate group（n＝10 in each group）．All rabbits were injected with 3% KCl and were treated with different ways．Results　 Typical ECG changes were found，and serum levels of [K+]were increased（P＜0.05）in all 30 rabbits in three groups after injection of 3% KCL．After treatment，compared with Saline group，serum levels of [k+] were decreased significantly （P＜0.05）and ECG recovered to normal in glucose-insulin group and sodium bicarbonate group．Conclusion　 “Intravenously guttae”is a simple and steady way of preparation of hyperkalemia model. Glucose-insulin and sodium bicarbonate are effective methods for the treatment of hyperkalemia.