Abstract: ［Abstract］Objective　To prove the inhibition effects of combination of indomethacin and tea polyphenols on growth of Lewis pulmonary tumor（LLC）in mice．Methods　LLC transplant model was built in mice．The model mice were divided randomly into 4 groups：control group，indomethacin group，tea polyphenols group and combination administration group．The tumor volume change and tumor suppressor rate of LLC in mice in four groups were observed．Results　The indomethacin and tea polyphenols group had obvious inhibiting effect on the transplanted Lewis pulmonary tumor in mice，compared with control group（P＜0.05）．The inhibiting effect was enormously enhanced by drug combination of indomethacin and tea polyphenols．Conclusions　Combination of indomethacin and tea polyphenols has obvious inhibition effect on the tumor growth of transplanted Lewis pulmonary tumor in mice，which could significantly enhance the inhibition effect to a certain degree，compared with independent administration.