Abstract: ［Abstract］Objective　To explore the correlation between lower extremity atherosclerosis（LEA）and bone mineral density in type 2 diabetes mellitus（T2-DM）patients．Methods　Two hundred and nineteen T2-DM were enrolled in this study．Severity of LEA was examined by Doppler Ultrasound of Aloka -α 10（Japan）. According to severity of LEA score，the subjects were divided into the control（n＝65），mild（n＝62），moderate （n=56）and severe（n=36） groups. The bone mineral density （BMD）in lumbar vertebrate and femoral bone was measured by Dual-energy X-ray absorptiometry（ DEXA）made in America．The clinical factors and biochemical parameters of patients in different groups were observed and the correlation between lower extremity atherosclerosis and bone mineral density．Results（1） With the increase in the severity of LEA，the HBA1c，FBG， 2HPBG， TC， TG and LDL were gradually increased ，but HDL was decreased in the four groups， there was significant differences（P＜0.05）.（2）The severity score of LEA was negative correlated with the BMD in lumbar vertebrat and femoral bone.（3）Multivariate Logistic regression analysis showed the change of BMD，HBA1c and TC were major risk factors of LEA T2-DM .Conclusions With the increase in the severity of LEA in T2-DM，the decrease of BMD is more obvious．The decrease of BMD is a risk factor of LEA production and development．