Abstract: ［Abstract］Objective　To discuss the experience of ex-vivo liver resection combined with partial liver autotransplantation for hepatocellular carcinoma．Method　Clinical data were retrospectively studied in 1 patient with massive hepatocellular carcinoma treated by ex-vivo liver resection combined with partial liver autotransplantation in the Second Affiliatted Hospital of Kunming Medical University on October，2011．Results　 The patient underwent the operation successfully without severe complications such as hepatic failure，renal fail and hepatic encephalopathy．The liver function tests showed normal results with in 20 days after operation and the patient was discharged on the 22nd day postoperation．The patient had survived for 6 months and the liver function was normal without new neoplasms，and liver function without any abnormal sign of imaging．Conclusion　Ex-vivo liver resection combined with partial liver autotransplantation can treat patients with unresectable hepatic space-occupying lesions with routine method efficiently.