Abstract: ［Abstract］Objective　To investigate the clinical effect of the transplantation of autologous peripheral blood stem cells（TPBSC）for blood flow remodeling in ischemic tissue of diabetic foot．Methods　42 patients with diabetic foot from Yunnan Provincial Center of Vascular Surgery were enrolled in this study. 42 cases underwent the transplantation of autologous peripheral blood stem from march 2005 to December 2008．The multifunction monitoring device，dopplor ultrasound monitoring device，percutaneous oxygen partial pressure moni- toring device（TcPO2）and digital subtractionangiography（DSA）were used to assess the effect degree of limbs regional blood flow from cutaneous covering， blood vessel and blood between preoperative and post-operative， the follow-up time was one year．Results　The effect indexes of limbs regional blood flow of the case by transplantation of autologous peripheral blood stem cells were as follows: skin temperature index（STI）was（1.6±0.3），percutaneous oxygen partial pressure monitoring device（TcPO2）was（37.6±9.5）mmHg，ankle-brachium index（ABI）was （0.9±0.2），photoplethysmography index（PPGI）was（0.8±0.1），saturation of blood oxygen（SaO2）was（79.4±20.4）percent，digital subtraction angiography score（DSAS）was（1.3±0.2），distance of intermittence limp was （46.2±10.6）meters．Conclusion　Transplantation of autologous peripheral blood stem cells can improve the blood flow remodeling in ischemic tissue of diabetic foot .