Abstract: ［Abstract］Objective　To explore the curative effect and toxicity of radical radiation therapy combined with S-1 for early nasopharyngeal carcinoma．Methods　From Jan.1st 2009 to Jan.1st 2010，88 cases of early early nasopharyngeal carcinoma were divided into two groups: the joint S-1 and radiotherapy group（experimental group） and the single radiotherapy group（control group）， and 44 cases in each group. Patients in the control group only received radiation therapy，they were adopted ordinary radiation therapies，five times a week，2.0 Gy each time， total dose was 60 ~ 66 Gy．Patients in the experimental group took S-1 capsules orally while receiving radiation therapy， the initial dose was 65 mg/(m.d)，bid，d1～d28 and the intermittent period was twoweeks．Results　All of the 88 patients completed treatment， and were evaluated as CR，the effective rate was 100%．2-year local control rates were 100%（44 / 44）for experimental group and 90.9%（40/44）for control group，there was significant difference（P＜0.05）between two groups．The main side effects were myelosuppression and gastrointestinal reactions．Conclusions　Radiation therapy combined with S-1 get higher local control ratio than single radiation therapy．But the long-term outcomes and toxicities need to be further investgated.