Abstract: ［Abstract］Objective　To compare the clinical methods and effects between holmium laser and pneumatic ballistic lithotripsy in treatment of kidney stone．Methods　99 patients with kidney stones from may 2011 to March 2012 were divided into 2 groups:study group and control group．The 44 patients in study group were given holmium laser lithotripsy，44 patients in contral group got pneumatic ballistic lithotripsy. We observed the patient operation time， intraoperative amount of bleeding，gravel rate，stones exhaust net time，clinical complications， the average hospitalization time and compared them between groups．Results　The two groups in the operation had better therapeutic efficacy and safety，for pneumatic ballistic lithotripsy intraoperative，the amount of bleeding was （88.2±2.3）， complication rate was 11.36%，for the holmium laser lithotripsy intraoperative amount of bleeding was（62.8±2.0）mL， complication rate was 4.55%，which were significantly lower than pneumatic ballistic lithotripsy （P＜0.05）；Holmium laser lithotripsy shortened hospitalization time（P＜0.05），but had no change in operation time（P＞0.05）． Conclusion　Compared with pneumatic ballistic lithotripsy，holmium laser lithotripsy in treatment of kidney stone has better efficacy and safety， can reduce the amount of bleeding and intraoperative complications，and shorten hospital stay.