Abstract: ［Abstract］Objective　To investigate the value of multiple parameters of high frequency color Doppler ultrasound in differential diagnosis of breast phyllodes tumor and breast fibroadenoma．Methods　We retrospectively analyzed the data of 30 cases of breast phyllodes tumor and 120 cases of fibroadenoma patients who received preoperative ultrasound examination and postoperative pathology confirm（ histopathological findings as a gold standard for diagnosis）. Results　Patients with breast phyllodes tumor were older than those with breast fibroadenoma，and the difference was statistically significant（ P＜0.05）．Two-dimensional ultrasound showed there were statistically significant differences in tumor shape， capsular integrality，internal echo homogenety，the presence of cystic degeneration，posterior echo attenuation between breast phyllodes tumor and breast fibroadenoma（P＜0.05）．Color Doppler flow grading showed statistically significant difference between breast phyllodes tumor and breast fibroadenoma（P＜0.05）．Pulsed Doppler artery resistance index（ RI ）and peak systolic velocity（Vmax）had statistically significant difference between breast phyllodes tumor and breast fibroadenomae（P＜0.05）．Conclusions　Breast phyllodes tumor and breast fibroadenoma have ultrasonographic features. For patients in older age， with lobular mass，incomplete envelope， uneven internal echo， cystic masses，rear echo attenuation and abundant blood flow in tumor，increase of arterial resistance index（RI ）and peak velocity（Vmax ，breast phyllodes tumor may be considered， but high frequency ultrasound parameters for the differential diagnosis of benign tumor and malignant tumor still needs further research.