Abstract: ［Abstract］Objective　To observe the efficacy of Panax notognsens（PNS）combined with heparin in the treatment of hypercoagulable status and hperlipidemia in children with nephrotic syndrome．Methods　128 in-patient nephrotic syndrome children with hypercoagulable and hperlipidemia were selected and were treated with full Dosage Prednisonum［2 mg/(kg.d)，maximal dose 60 mg/d］and were randomly divided into 3 groups：heparin group［Prednisonum+heparin 125 u/(kg.d)，n＝42］，PNS group［Prednisonum+PNS 10 mg/(kg.d)，n＝43］and therapeutic alliance group［Prednisonum+heparin 125 μ/(kg.d)+PNS 10 mg/(kg.d)，n＝43］．The treatment lasted for 4 weeks．24 hours urine protein，blood Alb，Chol，TG，BUN，Scr and blood clotting function（PT， APTT，Fg，DD）were detected before and after 3 weeks of treatment．Results　The complete remission rate of therapeutic alliance group was 81.40%，which was significantly higher than that of heparin group and PNS group（P＜0.05）． 24 hours urine protein，blood Chol，TG and blood Fg，DD were significantly decreased and blood Alb was significantly increased after treatment than before（P＜0.05）．The changing of 24 hours urine protein and blood Alb of therapeutic alliance group was significantly different compared heparin group and PNS group（P＜0.05）．The blood Chol and TG of therapeutic alliance group and PNS group were significantly decreased than that of heparin group（P＜0.05）．The blood Fg and DD of therapeutic alliance group was significantly decreased than that of heparin group and PNS group（P＜0.05）．Conclusion　PHS combined with heparin has better effect in the treatment of children with nephritic syndrome complicating with hypercoagulable status and hyperlipidemia.