昆明地区0～12岁儿童血浆25-(OH)D水平
Levels of 25-(OH)D in 0～12 years Old Children in Kunming
-
摘要: 目的 了解昆明地区0~12岁儿童血浆25-(OH)D的水平和现状.方法 应用罗氏公司Roche cobas 8 000/E602全自动电化学发光免疫分析系统对昆明地区4区8县0~12岁4 489例儿童进行血浆25-(OH)D水平的检测,应用SPSS统计软件进行统计分析.结果 随着年龄的增大,血浆25-(OH)D浓度逐渐降低,各年龄组血浆浓度比较差异有统计学意义(P<0.05);男女2组血浆25-(OH)D浓度比较,结果差异无统计学意义(P>0.05);昆明地区儿童维生素D平均水平是83.48 nmol/L,0-1岁组儿童血浆25-(OH)D浓度呈分散性分布,6~9岁组血浓度分布最集中.结论 昆明地区0~12岁儿童维生素D水平总的处于一个良好的营养状况,但随着年龄的增长,维生素D营养水平逐渐降低,尤其3岁以后降低明显,均处于不足或缺乏状态,应引起大家的重视.Abstract: Objective To learn the levels of serum 25-(OH)D in 0~12 years old chindren in Kunming.Methods Serum 25-(OH)D levels of children(4 498) were measured by using Roche cobas 8 000/E602 automatic electrochemical luminescence immunoassay.Results As the increase of age,the levels of serum 25-(OH)D were gradually decreased,different age groups had significant difference(P<0.05).The levels of 25-(OH)D between boys and girls had no significant difference(P>0.05);The average level of sernm 25-(OH)D was 83.48 nmol/L,the level of serum 25-(OH)D was distributed in 0~1 years old group,and most concentrated in the 6~9 years old group.Conclusion The levels of 25-(OH)D in 0~12 years old chindren are in a good status,but with the increase of age,the level of 25-(OH)D is decreasing gradually, especially the levels of 25-(OH)D decreased significantly after the age of three, in shortage or lack of status, this should cause everybody's attention.
-
[1] [1]HOLICKMF.Resurrection of vitamin D deficiency and rickets[J].Clin Invest,2006,116(8):2062-2072. [2] [2]HOLICKMF.Vitamin DDeficiency[J].N Engl Med,2007,357(7):266-281. [3] [3]ANNWEILER C,DURSUN E,FERON F,et al.Vitamin D and cognition in older adults:updated intemational recommendations[J].J Interm Med,2015,277(1):45-57. [4]李娈娈,余晓丹.维生素D与睡眠关系的研究进展[J].中华儿科杂志,2014,52(4):263-266. [5]朱庆龄,盛晓阳.维生素D过量及中毒的研究进展[J].中华儿科杂志,2015,53(3):235-237. [6]阎雪,张会丰,王卫平.重新认识机体维生素D营养状况[J].中华医学杂志,2012,92(20):1369-1371. [7] [7]GREER F R.Vitamin D deficiency:It’s more than rickets[J].J Pediatr,2003,143(5):422-423. [8] [8]ROTH H J,SCHMIDT-GAYKH,et al.Accuracy and clinical implications of seven 25-hydroxyvitamin D methods compard with liquid chromatography-tandem mass spectrometry as a reference[J].Ann Clin Biochem,2008,45(2):153-159. [9] [9]LENSMEYERGL,WIEBEDA,BINKLEYN,et al.HPLC method for 25-hydrxyvitamin D measurement:comparison with contempouauy assays[J].Clin Chem,2006,52(6):1120-1126. [10]邵洁.儿童维生素D、钙营养与骨健康[J].中国实用儿科杂志,2012,27(3):161-165. [11] [11]WOOTTONAM.Improving the measurement of 25-hydrox yvitamin D[J].Clin Biochem Rev,2005,26(8):33-36. [12]付彬彬,庞春玉,吴学礼.海口市3岁以下儿童维生素D水平分析[J].海南医学,2010,21(22):67-68. [13] 刘湘云,陈荣华,赵正言,等.儿童保健学[M].第四版,北京:人民卫生出版社,2011:296-305. [14]莫丽亚,黄彩芝,邓永超,等.湖南地区少年儿童维生素D营养状况分析[J].中国妇幼保健,2012,27(31):4926-4928. [15]梁冠禹,秦锐,张晓洁,等.南京市儿童血浆25羟维生素D、甲状旁腺激素和骨特异性碱性磷酸酶水平调查[J].中国儿童保健杂志,2009,17(1):17-20. [16]李小姗,徐玉琪,姜柳娴,等.6例佝偻病活动期25-羟维生素D3等指标的临床报道[J].昆明医科大学学报,2014,25(6):159. -
点击查看大图
计量
- 文章访问数: 2090
- HTML全文浏览量: 772
- PDF下载量: 89
- 被引次数: 0
下载:
