Abstract: ［Abstract］Objective　To explore the lung cancer related specific miRNA for judging the pathological type and disease progression．Methods　The 47 samples were got by multi-stage randomized sampling. TRIzol was used to extract the total of RNA from tissue samples，real-time SYBR Green fluorescent quantitative polymerase chain reaction（PCR）was used for quantitative detection of miRNA-192. The experimental data were statistically analyzed by the SPSS software．Results　The expression levels of miRNA-192 in lung cancer tissues of patients severe smoking（over 3 cigrattes one day for more than 2 years ）and drinking were significantly higher than that in patients without smoking and drinking or mild smoking（less than 3 cigrattes one day or less than 2 years）. In the 47 cases， the expression of miRNA-192 had no significant difference in lung cancer tissues （△CT=8.19±2.94） and in normal lung tissues（7.42±2.64）（P＞0.05）. There was no correlation between the expression of miRNA-192 in lung cancer tissues and the clinical data．Conclusions　MiRNA-192 is up-regulated in the population with risk factors such as smoking and drinking， and plays an role in the pathogenesis of lung cancer.There was no significant difference in miRNA-192 expression between lung cancer tissues and normal lung tissues，so we can't make sure miRNA-192 as a oncogene or suppressor gene of lung cancer. miRNA-192 can't be used in judging the pathological types，staging and prognosis of lung cancer.