Abstract: ［Abstract］Objective To compare the toxicities and recurrence rate with concomitant chemoradiotherapy（CRT） and radiotherapy（RT） alone after radical surgery for high-risk endometrial cancer. Methods A total of 43 patients with high-risk endometrial cancer who received standard surgery treatment from Yunnan Cancer Hospital between Oct. 2011 to Jun. 2014 were selected in this study. CRT was given to 21 patients and RT was given to 22 patients. The toxic reactions and the recurrence rate were compared between two groups. Results In Concurrent chemotherapy and radiotherapy alone group, the incidence of Grade 3 gastrointestinal reaction was 61.90% and 31.82% respectively，the difference was statistically significant（P <0.05）; the incidence of Grade 2 marrow suppression was 66.67% and 18.18% respectively，the difference was significant（P <0.01）；the incidence of Grade 2 neurotoxicity was 33.33% and 13.64%，respectively（P > 0.05）；the overall recurrence rate was 4.76% and 27.27%, respectively （P ＜0.05）. Conclusion　Compared with the simple radiotherapy，after the concurrent chemoradiotherapy, the incidence of Grade 3 gastrointestinal reaction may increase，the incidence of Grade 2 Bone marrow suppression may also increase significantly，while the incidence of peripheral neurotoxicity may not increase，the toxicity is acceptable, and the 2-year recurrence rate may decrease.