Abstract: ［Abstract］Objective　To investigate the clinical efficacy and safety of decreasing blood uric acid by benzene bromine Malone in treatment of hyperuricemia with elderly hypertension and diabetes mellitus. Methods All 100 hyperuricemia in elderly patients with hypertension and diabetes mellitus received the standard drug treatments for blood pressure and blood sugar management. They were divided into study group（uric acid intervention group）and control group. Patients in the study group were given low purine diet and benzbromarone tablet （50 mg/day，course of 1 year）， while patients in the control group were only given low purine die. The indexes of the curative efect and security were the metabolism indexes such as blood uric acid and renal function as well as blood blood sugar and pressure. At the same time we evaluated systemly the side effects of rashes， digestive system， nervous system and urinary system. Results （1）In study group， 3 months， 6 months and 1 years after intervention， the serum uric acid levels were significantly lower than that before intervention and the control group（P＜0.01）. （2）The study group patients' ambulatory blood pressure was significantly lower than that before intervention and the control group after 6， 12months， meanwhile the study group patients' success rate of ambulatory blood pressure level was higher than themselves before the intervention after 6， 12months（P ＜0.05）. （3）The 2 groups of patients' metabolic indexes of related blood sugar and renal function had no difference at each testing point before and after the intervention. （4） Except 2 cases of digestive tract symptoms occurred but tolerated in the 2 groups， there had no other adverse reactions. Conclusion Long-term decreasing blood uric acid with benzene bromine Malone has good efficacy and tolerance.