Abstract: ［Abstract］Objective To evaluate the short-time prognostic value of combination of Heart-type fatty acid-binding protein (H-FABP) and simple Pulmonary Embolism Severity Index (sPESI) in normotensive patients with acute pulmonary embolism (APE). Methods　One hundred and thirty normotensive patients with APE were enrolled. The plasma concentration of H-FABP was analyzed and the sPESI scores were calculated．Result　13(10%) patients had adverse 30-day outcome. The H-FABP［OR, 4.96（1.70-14.42），P = 0.003］and sPESI ［OR, 9.50（2.24-40.28），P = 0.002］were predictors for short-term prognosis of normotensive APE. All of the 30 patients (23.1%) with sPESI score 0 and H-FABP＜6 μg/L had no adverse 30-day outcome. The combination model of H-FABP ≥6 μg/L with sPESI≥1 point(s) was associated with increased prognostic sensitivity and negative predictive value, which both reached 100%．Conclusions　The H-FABP assay and the sPESI are useful prognostic indicators for 30-day outcome of normotensive APE. The combination of the both predictors can yield additive prognostic information and particularly identify low-risk patients with APE.