Abstract: ［Abstract］Objective To investigate the effects of TB drugs combined with rifapentine on the immune function， inflammatory factors，VEGF and MMP-9 of patients with pulmonary tuberculosis. Methods Sixty cases of tuberculosis patients were randomly divided into control group（n = 30） and observation group （n = 30）. The control group was given rifapentine，while the treatment group was given tuberculosis pill treatment based on rifapentine. The immune function， inflammatory factors，VEGF and MMP-9 levels of patients before and six months after treatment between the two groups. Results　After treatment， the levels of CD3+， CD4+ and CD4/CD8 of patients in the two groups were increased significantly（P＜0.05）. After treatment， the levels of CD3+， CD4+ and CD4/CD8 of patients in the observation group were significantly higher than those in the control group（P＜0.05）. Compared with before treatment， after treatment INF-γ levels were significantly increased（P＜0.05）， IL-4， CRP， TNF-α levels were significantly lower （P＜0.05）. Compared to the control group after treatment and observation Group INF-γ levels were significantly higher （P＜0.05）， while IL-4， CRP， TNF-α levels lower（P＜0.05）. Compared with before treatment， the serum MMP-9， VEGF levels were significantly lower after treatment （P＜0.05）. Compared with the control group， the serum MMP-9， VEGF levels of patients in the observation group were significantly lower after treatment（P＜0.05）. Conclusions　 Tuberculosis drug combined with rifapentine can significantly improve the immune function of TB patients， reduce inflammation， reduce VEGF and MMP-9 levels， so as to effectively control the disease， has important significance， and is worthy of further application.