Abstract: ［Abstract］Objective　To observe the efficacy and safety of fusidic acid cream and halometasone cream in the treatment of psoriasis vulgaris. Methods　Fifty-four patients with psoriasis vulgaris were enrolled in this study and were divided into observation group and control group. 26 patients in observation group were treated with halometasone cream, 28 patients in control group were treated with fusidic acid cream combined with halometasone cream. The psoriasis area and severity index（PASI）and abverse events of treatment were recorded. At the same time，34 normal people taking physical examination were selected as health group，the infections of pathogenic microorganism were compared between psoriasis vulgaris patients and normal people. Results　The pathogenic infection rate of patients with psoriasis vulgaris was 72.22%, the infection rate was 75.00% in observation group and 69.23% in control group. The infection rate in health group was 38.24%，the difference in the pathogenic infection rate was statistically significant between paitents with psoriasis vulgaris and normal people（P＜0.05）. After treatment, the rate of negative infections was 95.24% in observation group and 72.22% in control group, there was significant difference between two groups（P＜0.05）. The PASI scores and VAS scores of observation group were significantly lower than those of control group（P＜0.05）. The total effective rate of treatment was 71.43% in observation group and 34.62% in control group，the difference was statistically significant（P＜0.05）. There was no significant difference in rate of adverse events between observation group and control group（P＞0.05）. Conclusion　The pathogenic infection is closely correlated with psoriasis vulgaris，fusidic acid cream combined with halometasone cream has good efficacy and safety in treatment of psoriasis vulgaris and worth of popularization and application.