Abstract: ［Abstract］Objective To analyze the effect of early intervention in neurodevelopment on the motor and cognitive development of high risk premature infants. Methods 82 children with high risk premature infants in weinan central hospital from May 2013 to February 2015 were selected and randomly divided into control group （41 cases） and observation group （41 cases）. Patients in the control group were given a conventional treatment and care，J62 while patients in the observation group were given early intervention in neurodevelopment. The motor and cognitive development of patients in the two groups was compared. Results PDI scores of patients in the observation group were（85.74±16.80），（94.56±15.68），（86.52±16.34）and（87.21±16.85）in 3，6，9 and 12 months， which was significantly higher than those in the control group［（60.52±13.57），（72.15±15.38）， （62.68±15.94）and（63.92±13.80），P < 0.05］，respectively. MDI scores of patients in the observation group were（83.52±12.58），（93.48±13.57）and（85.91±16.27）in 3，6 and 9 months，which was significantly higher than those in the control group［（61.35±13.57），（71.26±15.34）and（61.45±15.28）， P < 0.05］， respectively. The incidence of cerebral palsy in the observation group （2.4%） was lower than that in the control group （4.9%）， but there was no significant difference（χ2 = 0.346，P = 0.556）. Conclusion In the treatment of high risk premature infants， early intervention in neurodevelopment can improve the motor and cognitive development， which is worthy of application.