Abstract: ［Abstract］Objective　To investigate the application value of ultrasound elastography and two-dimensional ultrasound in benign and malignant lesions of liver. Methods 84 patients with liver disease were selected as research objects who underwent preoperative ultrasound elastography and conventional ultrasonography from June 2012 to June 2014. A comparison was made between the results of imaging diagnosis and surgical pathology. Results There were 38 cases （68 lesions） of benign malignant liver lesions and 46 cases of malignant tumors（82 lesions）. For benign and malignant lesions，the diagnostic accuracy，sensitivity and specificity of dimensional ultrasound diagnosis were 76.47% and 82.93%，70.25% and 68.23%，and 62.45% and 72.32%，respectively. However， the diagnostic accuracy，sensitivity and specificity of ultrasound elastography were 91.17% and 95.12%， 93.65% and 90.25%，and 80.25% and 88.92%， respectively. There were the statistically significant differences between the two methods（P < 0.05）. Compared with benign lesions，malignant lesions showed higher grading using ultrasound elastography，with a statistically significant difference（P < 0.05）. Conclusion Ultrasound elastography technique provides a new method to diagnose the liver diseases，which can improve the accuracy and sensitivity of the diagnosis of benign and malignant lesions.