Abstract: ［Abstract］Objectives The goal of this study was to analyze the clinical significance of platelet distribution width（PDW）and mean platelet volume（MPV）levels in the prognosis of chronic obstructive pulmonary disease （COPD）combined with pulmonary artery hypertension（PAH）. Methods In a retrospective study， we identified 498 patients with COPD from January 2012 to December 2013 in the second people's hospital of Qujing， 216 of them combined with PAH. We recorded the clinical data， results of blood gas analysis and echocardiography and measured the levels of PDW，MPV and NT-proBNP after admission. The results were statistically analyzed by the statistical package for social sciences（SPSS version 18.0） and software SAS JMP 9.0. Results The levels of PDW［（17.9±1.9%）vs（16.9±2.3）%，P＝0.008］， MPV ［（13.9±1.5）fL vs（12.4±2.1）fL，P＝0.002］and NT-proBNP［（1521.4±925.7）pg/mL vs（691.9±364.5）pg/mL，P＜0.001］in COPD with PAH group were significantly higher than those in COPD without PAH group. At follow up of 12 months， patients with readmission or death had higher values of PDW［（19.1±1.8）% vs（17.6±1.4）%，P＜0.001］and MPV ［（14.5±1.5）fL vs（13.7±1.4）fL，P＝0.002］. Kaplan-Meier survival analysis showed that the rate of readmission and death after 12 months was significantly higher in patients with higher values of PDW（P＝0.018） and MPV （P＝0.016）. Conclusions　The detection of PDW and MPV has great signification for the prediction of long-term outcomes in COPD combined with PAH.