Abstract: ［Abstract］Objective　To investigate the effect of high homocysteine on blood glucose control in type 2 diabetic patients. Method We selected 186 cases of organic disease that without diabetes acute and chronic complications，and ruled out the type 2 diabetic patients with organic disease，these enrolled cases were divided into two groups according to Homocysteine（Hcy）levels，group 1（Simple diabetes）70 cases and group 2 （diabetes with high Hcy）116 cases. According to the different intensity of the drugs，different weights were given to calculated index of hypoglycemic agents，and then the difference of the drug use index between the two groups at the same Condition of HbA1c and FPG was observed．Results　In group 1 and group 2，Hcy levels were 8.33 ± 1.16 and 14.53 ± 4.74， respectively；comprehensive treatment indexes were （4.9 ± 2.63）and（7.16 ± 2.16）， respectively. Composite index had a significant difference between the two groups（P < 0.05）; The level of Hcy was positively correlated with the index of Comprehensive drug （r＝0.252， P < 0.01）. Conclusion　Glucose lowering therapy for diabetic patients with high Hcy is more complex and difficult than for the simple diabetic patients