Abstract: ［Abstract］Objective　To investigate the clinical effect of different doses of esomeprazole in treatment of nonvariceal upper gastrointestinal bleeding（ANVUGIB）．Methods　We collected the data of 90 patients with ANVUGIB admitted in our hospital from August 2014 to October 2015. The 90 patients were divided into 2 groups: treatment group and control group. Patients in both group were given the combination of Octreotide and other treatment，patients in the treatment group were given continuous pumping of 8 milligrams of esomeprazole per minute for 72 hours after intravenous injection of 80 mg of esomeprazole， patients in the control group were given intravenous instillation of 40 mg of esomeprazole every 12 hours. Then we compared the clinical effect between two groups. Results　In the two groups，we statistically analyzed the number of effective cases according to the gender（male and femal），age over 60 years old， and the hemoglobin less than 70.0 grams，there was a statistical significant difference （P < 0.05），suggesting that the number of effective cases in the treatment group was higher than that in the control group. The average hospitalization days of patients in the treatment group and the control group was （7.3 + 2.4） days and （9.5 + 3.6） days， respectively，there was a statistical significant difference（P < 0.05）. The blood transfusion volumes of patients in the treatment group was less than that in the control group.Conclusion　On the basis of octreotide treatment，continuous pumping of 8 milligrams of esomeprazole per minute after intravenous injection of 80 mg of esomeprazole has better hemostatic effect， shorter hospitalization time， and less blood transfusion volume in treatment of nonvariceal upper gastrointestinal bleeding， so it is worthy of clinical promotion.