Abstract: ［Abstract］Objective　To study the clinical application and therapeutic effect of new adjuvant chemotherapy combined with operation treatment and single operation treatment in treatment of stage Ib2-II a locally advanced cervical cancer . Methods　Forty patients with stage Ib2-IIa locally advanced cervical cancer treated in our hospital were divided into two groups，respectively treated by different methods. The observation group of 20 cases was gvien the new adjuvant chemotherapy combined with operation therapy；while the control group of 20 cases accepted the direct operation treatment. Then we compared tumor changes，the operation time，intraoperative bleeding volume， the rate of positive margins and metastatic lymph node ratio of patients after chemotherapy between the two groups， and evaluated the clinical application value of new adjuvant chemotherapy combined with operation treatment。 Results　After chemotherapy， the patients' tumor size was smaller than that before chemotherapy in the observation group （P＜0.05）， the operation time and bleeding volume was significantly less in the observation group than those of the control group （P＜0.05）， the observation group margin positive rate and the lymph node metastasis positive rate were significantly lower than those of the control group， there was a statistically significant difference between them （P＜0.05）．Conclusions　In the treatment of stage Ib2-IIa locally advanced cervical cancer， new adjuvant chemotherapy combined with operation therapy methods is more effective than single operation therapy， and the clinical effect is better，too.