Abstract: ［Abstract］Recent studies have shown that the process of organization and recanalization of venous thrombus is similar to the wound healing process， both are associated with the venous wall inflammation，a variety of inflammatory cell infiltration and neovascularization. Remarkably，high concentrations of MCs/Mphs also are detected in the regions of recanalization，both in spontaneous human and in experimental animal thrombi，suppression function of mononuclear macrophages can inhibit thrombus dissolving process. Otherwise，a lot of experimental data suggest a role of blood-borne mononuclear cells，including mononuclear-derived macrophage in organization，vascularization，and recanalization of thrombi. Now this paper will review the mechanism and research progress of MCs/Mphs in promoting Vein Thrombosis organization and recanalization.