Abstract: ［Abstract］Objective To evaluate the early effect and safety of artificial hip replacement for treating senile osteoporosis femoral neck fractures with different prostheses choice. Methods From January 2006 to April 2014， 387 patients with senile osteoporotic femoral neck fractures received artificial hip replacement. Their average age was 65 to 98 years old， with the average of 76.9 years old. Four prostheses were used in the artificial hip replacement， including 107 cases of biological total hip，94 cases of bone cement type total hip，104 cases of biotype artificial femoral head，and 82 cases bone cement artificial femoral head. We compared the operation time，bleeding amount，postoperative ambulation time，postoperative complication rate among the four prostheses. Results The biological hip replacement were superior to bone cement type in the operation time（50±10.3 min vs 61±11.5 min），bleeding amount（149±27.7 ml vs 205±47.3 ml） and postoperative complications（21% vs 38%），with statistical significant differences（P < 0.05）. Other observations showed no statistically significance. Conclusion The biotype artificial joint replacement is applicable to the younger patients with thick bone cortex and long life expectancy， while the bone cement artificial joint replacement is appropriate for weak senile patients with thin bone cortex.