Abstract: ［Abstract］Objective To evaluate the clinical efficacy of the local drug resistance spectrum antibiotics and foreign guideline in the treatment of patients with community acquired pneumonia（CAP）. Methods A prospective，randomized，single blind，and positive drug parallel controlled design was used in the treatment. CAP patients with no underlying disease outpatients and inpatients＜48 hours were selected as the research object. The patients in the trial group were given sensitive local drug resistance spectrum antibiotics: moxifloxacin，400 mg and 1 times a day. The patients in the control group were given azithromycin tablets（each 500 mg，once daily） promulgated by the 2007 version of the IDSA / ATS adult CAP guideline. Results There were 106 cases of CAP patients， of which 77 cases completed treatment， including 39 cases in the experimental group and 38 cases in the control group. There were significant differences in the clinical efficacy and bacterial clearance rate between the two groups， with the clinical efficacy of 89.7% and 68.4%（P < 0.01），the bacterial clearance rate of 87.9% and 54.5%（P < 0.05）， respectively. Conclusion The clinical efficacy of drug resistant spectrum sensitive antibiotics in the treatment of CAP in Kunming was better than that of IDSA/ATS. Clinicians should pay attention to the characteristics and composition of resistance of common pathogenic bacteria in our country during the study and reference from foreign guideline，and adjust the therapeutic regimen according to the changes of the local drug resistance monitoring data rather than copy the recommended treatment plan by foreign countries.