Abstract: ［Abstract］Objective To discuss the applied research of CT perfusion imaging on the diagnosis of splenic diseases. Methods 20 patients with splenic diseases which accepted treatment in our hospital from January 2012 to December 2014 were assigned into group A， including 7 cases of splenic lymphoma patients（group A1）， 8 cases of leukemia patients with spleen infiltration （group A2） and 5 cases of splenic metastasis（group A3）. At the same time， 20 healthy persons were selected as the control （group B）. Results The result of CT scan was normal in group B， but that showed a variety of lesions in the spleen in group A. The spleen perfusion volume in the group A was significantly higher than that in the control group （P＜0.05）. The detection rate of CT perfusion imaging was significantly higher than that of CT scan （P＜0.05）. TIP and MTT in group A were significantly higher than those in group B，while BF， PEI and BV were significantly lower （P＜0.05）. Conclusion CT perfusion imaging has advantage of simple， short imaging time，less trauma，and a high diagnostic value for the spleen disease， which is an ideal detection means and can be used in clinic.