Abstract: ［Abstract］Objective To analyze the situation of health-risk behaviors of the students in specialty medical science college of Yunnan and its relationship with negative life events， and provide scientific evidence for lowering the occurrence rate of health-risk behaviors. Methods The stratified randomised cluster-sampling method was used to select 576 students of specialty medical science college， and the occurrence rate of health-risk behaviors and life events conditions were estimated by Youth Health-Risk Behavior Questionnaire and Adolescents Self-Rating Life Events Checklist. Descriptive statistic analysis， Chi-square test and Logistic regression analysis was used to analyze the data. Results Among the students of specialty medical science college in Yunnan， the rate of smoking was 3.1%，the rate of drinking was 4.9%，the rate of food refusal was 39.6%， the rate of fighting was 13.5%，the rate of obsessed with the internet was 26.4%，and the rate of substance abuse was 3.1%. There were significant differences between the students of different genders（P＜0.05） or specialities（P＜0.05）. Logistic regression analysis showed total score of negative life events had positive influence on drinking （OR=1.017，P＜0.05）， food refusal （OR＝1.018，P＜0.05）， fighting （OR＝1.021，P＜0.05）， obsessed with the internet（OR＝1.025，P＜0.05）， substance abuse（OR＝1.025，P＜0.05）. The factor of interpersonal relationship had positive influence on drinking（OR＝1.162，P＜0.05）， food refusal（OR＝1.102，P＜0.05）， substance abuse（OR＝1.260，P＜0.05）. The factor of punished had positive influence on fighting（OR＝1.144，P＜0.05）， and had negative influence on drinking（OR＝0.891，P＜0.05）. The factor of study pressure had positive influence on fighting（OR＝1.143，P＜0.05）， and the factor of loss had negative influence on fighting（OR＝1.144，P＜0.05）. Conclusion Negative life events are influencing factors for health-risk behaviors of the students in specialty medical science college of Yunnan， and there is difference on the way that the factor of life events influencing health-risk behaviors.