Abstract: ［Abstract］Objective To explore the short-term and long-term clinical effect of leep knife treatment of chronic cervicitis. Methods A single-center， prospective， randomized， controlled study was used， 120 patients with chronic cervicitis were randomly divided into observation group and control group， each group of 60 patients. Patients in the observation group were treated with （LEEP） knife， parameters setting frequency was 3.8 MHz， power was 30 ~ 40W， patients in the control group were treated with microwave. The intraoperative and postoperative recovery and relapse were compared between two groups. Results The intraoperative blood loss， operative time， postoperative vaginal discharge time in the observation group were significantly less than control group， there was a significantly statistical difference （P < 0.001）. After two weeks and three months ， the cure rate in observation group were 70% and 98.33% respectively， the cure rate in control group were 16.67% and 51.67%， there was a significantly statistical difference （P < 0.01）. After 2 weeks and 3 months， the infection rate and recurrence rate in the observation group were significantly lower than the control group， there was a significantly statistical difference （P < 0.05）. Conclusion　Leep knife for treatment of chronic cervicitis patients has lower postoperative recurrence， lower infection rate and higher cure rate in short-term and long-term， and less intraoperative trauma， shorter operation time， and has important clinical significance for the prognosis of patients.