Abstract: ［Abstract］Objective To study clinical effect of laparoscopy combined with gestrinone in treatment of ovarian endometriosis cyst and the prognoisi of patients. Methods A randomized， controlled， prospective study was used in this study， 78 patients with ovarian endometriosis cyst were selected in Sichuan province panzhihua city miyi people's hospital from august 2012 to august 2014， and were randomly divided into observation group and control group， 39 patients in each group. Patients in the observation group were treated with laparoscopy combined with gestrinone （2.5 mg/time， two times per week， for 6 months） intervention; patients in the control group were treated with laparoscopic intervention. After six months， the postoperative serum FSH （Follicle Stmi Ulating Hormone， FSH）， Estradiol （E2） and Estradiol levels， ovarian biggest plane average diameter （D）， the level of MMP-9 and TIMP -1 level， pregnancy outcome of two groups were compared and the outcome and the recurrence rate 18 months after treatment were followed up. Results Six months after treatment， the E2 and FSH levels in the observation group were better than control group， with statistically significant difference （P＜0.01）；the postoperative serum levels of MMP-9 and TIMP-1 in Observation group were better than control group， with statistically significant difference （P＜0.01）; there were 20 patients of D≤2 cm， 19 patients of D>2 cm， the postoperative ovarian shrink rate was 51.28% in the observation group; there were 5 patients of D≤2 cm， 34 patients of D>2 cm ovarian shrink ratio was 12.82% in the control group， the ovarian shrink ratio of observation group was obviously higher than control group，with statistically significant difference （P＜0.01）. Follow-up for 18 months， the recurrence rate was 5.13% in the observation group，which was significantly lower than thatin the control group（25.64%），with statistically significant difference（P＜0.05）; the pregnancy rate was 66.66% and 30.77% in the Observation group and control group， respectively，the difference had statistical significance（P＜0.01）. Conclusion Laparoscopic surgery combined with gestrinone can protect ovarian function of patients with ovarian endometriosis cyst，improve pregnancy outcomes， and reduce recurrence rate， and has good clinical value.