Abstract: ［Abstract］Objective　To study the safety and effect of ultrasound guided minimally invasive rotary cutting for treatment of benign breast lesions. Methods A single-center， prospective， randomized， controlled study method was used， 84 patients with breast benign lesions were randomly divided into observation group and control group， 42 patients in each group. Patients in the observation group were treated with ultrasound guided minimally invasive rotary cutting， patients in control group were treated with traditional surgery. The intraoperative and postoperative related indicators were compared between two groups. Results The intraoperative blood loss， length of incision， operation time in breast benign unilateral single and unilateral and bilateral lesions in the observation group were significantly less than those in the control group， with statistically significant difference（P＜0.01）. The healing time， postoperative pain score， complications in breast benign unilateral single and unilateral and bilateral lesions in observation group were less than those in the control group， with statistically significant difference（P＜0.01）. And the postoperative satisfaction， and the excellent rate of beauty in breast benign unilateral single、unilateral and bilateral lesions were better than control group， with statistically significant difference（P＜0.01）. There was no breast deformation in observation group after treatment， and there were 3 patients of breast deformation in the control group has 3 patients， accounting for 7.14%. Conclusion Ultrasound guided minimally invasive rotary cutting is significantly superior to the traditional treatment in security and effectiveness for treatment of breast benign lesions in one single and unilateral multiple and bilateral lesions.