Abstract: ［Abstract］Objective　To investigate the clinical effect of cisplatin combined with cisplatin and radiotherapy in the treatment of glioblastomas patients receiving surgery. Methods　68 cases of glioblastomas patients with surgery were divided into control group（n＝36） and treatment group（n＝32）. The control group was treated with temozolomide and radiotherapy；the treatment group was treated with cisplatin combined with temozolomide and radiotherapy. Short-term efficacy， adverse reactions， and survival time were documented during following up in both groups. Results　The efficiency in the treatment group （87.5%） was significantly higher than that in the control group （66.67%），P＜0.05. There were no significant difference of adverse reaction including bone marrow inhibition， digestive tract symptoms， and psychiatric symptoms among the two groups，P＞0.05. The medium survival time of the treatment group （26.0 month） was significantly longer than that of the control group （17.5 month）， P＜0.05. There was no significant difference of 1-year survival rate between the treatment group （81.25%） with control group （63.89%）， P＞0.05; however， 2- and 3-year survival rate in treatment group （52.13%， 31.25%） were significantly higher than that in the control group（27.78%，11.11%），P＜0.05. 1-year progression free survival （PFS） rate of treatment group （68.75%） was significantly higher that of control group （41.67%），P＜0.05. Conclusion Cisplatin combined with temozolomide and radiotherapy can significantly improve the treatment efficiency without leading to higher rate of adverse reactions and significantly improve the 2-， 3-year survival rate as well as 1-year progression free survival（PFS）rate in patients with glioblastomas，it is worth being promoted in clinical application.