Abstract: ［Abstract］Objective　To explore the clinical efficacy of theophylline retard-20 tablet in pediatric asthma treatment. Methods　From April 2010 to December 2014 in our hospital 136 cases of children with infantile asthma were selected and divided into observation group and control group. Patients in the observation group were treated with sulfate aerosol inhalation therapy，patients in the control group were given oral theophylline retard-20 tablet treatment. After treatment，the treatment results were analyzed. Results　In the observation group，functional recovery was found in 37 cases，significant progress in 20 cases，on effect in 11 cases，the total effective rate was 83.82%；Adverse reactions such as pharyngeal discomfort was found in 3 cases，upset stomach in 0 cases，heartburn in 0 cases，the incidence was 4.41%. In the control group，68 functional recovery was found in 19 cases，and remarkable progress in 26 cases，on effect in 23 cases， the total effective rate was 66.18%；Adverse reactions such as pharyngeal discomfort occurred in，4 cases，upset stomach in 3 case， heartburn in 4 cases，the incidence was 14.71%. The effect effective treatment was better than that of control group（P < 0.05），the incidence of adverse reactions in observation group was significantly lower than the control group （P < 0.05）. Conclusion　The treatment of infantile asthma with salbutamol sulfate aerosol therapy is very effective and has，clinical significance，is worth further promotion and application.