Abstract: ［Abstract］Objective　To explore the clinical therapeutic effects of postoperative intracranial infection in neurosurgery. Methods　Between January 2014 and January 2014， 50 patients with postoperative intracranial infection in the department of neurosurgery in our hospital were selected in this study. Among the 50 patients， 25 patients were treated by intravenous antibiotic therapy，15 patients were treated with intrathecal and intravenous antibiotics treatment，10 cases were treated by intrathecal injection， intravenous antibiotics and lumbar pool catheter drainage way for treatment， and then we observed the clinical therapeutic effect of three groups of patients. Results　In 50 patients， 37 patients were cured， 3 cases had marked effect， 8 patients had effect， 2 patients had no effect. Conclusion　For patients with neurosurgical operations， to maximally reduce the risk of intracranial infection， it is necessary to take antibiotics according to the actual situation of patients， and make different treatment schemes according to the difference of infection.