Abstract: ［Abstract］Objective　To explore the effect of comprehensive experiments on clinical practice of internal medicine nursing in the patients with advanced simulation human Simman3G. Methods　Two grades of nursing students were selected by random cluster sampling and divided into the experimental group and the control group. The control group used the traditional clinical probation method to carry out clinical probation teaching in Department of internal medicine，the experimental group used the advanced simulation human Simman3G to conduct a comprehensive simulation of teaching before clinical probation. After the completion of the internship the self compiled questionnaire was given to two groups of students to investigate their opinion on the clinical probation. Then we compared， the semester examination results between two groups. Results　In the experimental group，the grade of internal medicine nursing was higher than the control group at the end of the semester，P < 0.05. The results of questionnaire survey showed that there was no significant difference between the two groups in the promotion of theoretical knowledge and the two dimensions of the survey of nursing work environment. In the training of clinical thinking， improve nursing skill，communication skill， and the learning interest.At the great harvest of 5 dimensions of probation，the experimental group of students' recognition degree was significantly higher than the control group，P < 0.01. Conclusion　Before clinical probation of internal medicine nursing，the application of high-end analog teaching can significantly improve the effectiveness of clinical probation.