Abstract: ［Abstract］Objective To investigate the diagnosis and treatment of severe MT patients， and to add a reference for similar cases. Methods　From March 2014 to September 2015， the clinical data of 53 patients with severe MT in Liu'an First People’s hospital were retrospectively analyzed. Results　Four out of 53 cases of severe MT were missed diagnosis（missed diagnosis rate: 7.5%）；51 cases（96.2%）received surgical treatment；2 cases （3.8%）were treated by non operation， 45 cases（84.9%） were treated successfully， and 8 cases（15.1%） died. Among the 8 patients， 3 died of severe craniocerebral injury，2 cases died of MODS and sepsis，and 1 cases died of shock. Fifteen cases of primary thoracic and abdominal trauma patients with DCS after treatment were cured and discharged，among which PCT in the treatment of 2 d increased only at the beginning then gradually reduced after. CRP， IL-6 and IL-10 all showed a trend of decline. Compared with 7 d and 1 d， significant difference was shown （P＜0.01）. Conclusion　By clearly knowing the clinical characteristics of severe MT， accurate diagnosis should be made to avoid misdiagnosis. At the same time， we should pay more attention to the emergency treatment and the treatment of fatal injury.