Abstract: ［Abstract］Objective　To investigate the clinical efficacy and safety of laparoscopic appendectomy for acute appendicitis. Methods　Nighty-two cases of acute appendicitis were included in this study， randomly divided into observation group（n＝46） and control group（n＝46）according to the random number table method. The observation group was treated with laparoscopic appendectomy，and control group with the traditional open appendectomy treatment. We compared the two groups of cases in postoperative conditions and the level of WBC changes and 1d and 3d after operation. Results　The operation time of the observation group was shorter than that of the control group（t＝4.049，P＜0.05）；there was no significant difference in lymph nodes（t＝0.570，P＞0.05）；the amount of bleeding was less than that of the control group（t＝20.748， P＜0.05）. The get-out-of-bed activity time in the observation group was faster than the control group（t＝9.221，P＜0.05）; eating time was faster than the control group（t＝8.794，P＜0.05）；the anus recovery exhaust time was faster than the control group（t＝17.423，P＜0.05）；hospital stay was shorter than the control group（t＝13.479，P＜0.05）；the complication rate was lower than that of the control group（t＝13.883，P＜0.05）. The levels of 1d and 3d WBC were lower in the observation group than that in the preoperative group（t＝7.277，26.911，P＜0.05）；the levels of 1d and 3d WBC in the observation group were lower than those in the control group at the same time（t＝3.6189，17.827，P＜0.05）；the 3d WBC level of the observation group was lower than that of 1d（t＝20.732，P＜0.05）. Conclusion　Laparoscopic appendectomy is a safe and effective treatment for patients with acute appendicitis， and it is worthy of further clinical research.