Abstract: ［Abstract］Objective To investigate the clinical application effects of tracheal intubation under general anesthesia guiding by HC visual laryngoscope in combination with fiberoptic bronchoscopy via clinical studies. Methods A total of 348 patients underwent the tracheal intubation under general anesthesia in the hospital between January 2013 and January 2015 were randomly selected and Divided into three groups according to different ways of guiding tracheal intubation．The first group was a simple fiber light guide bronchoscopy to guide the general anesthesia tracheal intubation was set to F group,In the second group, the general anesthesia tracheal intubation was set to H group for the simple HC video．The third group was HC video mirror combined with fiber light guide bronchoscopy to guide the general anesthesia tracheal intubation was set to H+F group. The general condition and intubation conditions such as the time and frequencies of intubation in three groups were recorded respectively. Results The general condition，age，BMI index，thyromental distance， interincisor distance value were similar among three groups. The time needed for intubation was the longest in group F up to（41±11） s. The highest frequency of intubation was in group H with 30 times，and the time of glottis exposure was the longest in group F as（21±9）s. The difference among groups and intra-groups has statistical significance（P＜0.05）. Conclusion 　HC visual laryngoscope in combination with fiberoptic bronchoscopy guiding tracheal intubation under general anesthesia has a good effect in clinical practice，and is worthy of clinical promotion.