Abstract: ［Abstract］Objective　To observe the clinical curative effect of computer aided cognitive rehabilitation system for the treatment of cognitive impairment after stroke. Methods　The data of 70 cases of cognitive impairment after stroke patients were randomly selected from November 2011 - November 2012 in our hospital， according to the treatment method，patients were randomly divided into research group（n＝35） and control group （n＝35）. The control group patients were given cognitive training， sports and drugs and other conventional treatment. On the basis of conventional treatment ， the research group patients were given computer aided cognitive rehabilitation system treatment. Then we observed and compared the clinical curative effect of two groups of patients after treatment. Results　The cognitive rating scale（LOTCA）scores in patients in the research group was better than that in the control group， the difference was statistically significant（P < 0.05）. The simple mental state examination （MMSE） score of patients in the research group was better than that in the control group， the difference was statistically significant（P < 0.05）. Conclusion　Computer assisted cognitive rehabilitation system for patients with cognitive impairment after stroke has significant curative effect， and should be popularized and widely used in clinical treatment.