Abstract: ［Abstract］Objective　To study the influence of Naikan therapy on depression in patients with Schizophrenia. Methods　256 patients with Schizophrenia were divided into study group and control group according to the set sequence. The study group was simulated by Naikan therapy and the control group was given routine cure. All patients were assessed by Positive and negative symptom scale（PANSS），Simple coping style questionnaire （SCSQ），Defense way questionnaire（DSQ）， Hamilton depression scale （HAMD）， and Hamilton anxiety scale （HAMA）. Results　In the 6th week，the differences in HAMD score，Cover factor， negative coping were statistically significant between the two groups（t＝2.37，2.33，2.36，P＜0.05）. The differencs in HAMA score， Cover factor，negative coping were statistically significant between the 0th and the 6 th week in the study groups （t =2.31，2.42，2.47，P < 0.05）. The difference of PANSS score were statistically significant between the 0th and 6th week of the two groups. Conclusion　The Naikan therapy can improve the mental symptoms and depressive symptoms in patients with Schizophrenia.